I pulled this off the LymeNet Europe board. It’s a list of publications that have punctured holes in the claims and theories of self-styled “Lyme literate” doctors. Every time some quack comes up with a new way to diagnose Lyme or tries to associate Lyme with some complex neurological illness competent, credible scientists try to replicate their results…and fail. That’s how science works, but Lyme activists and their quack doctors don’t much like it.
I’ve added a few more examples to the original list.
The recent failure of CDC scientists to replicate the findings of Sapi and the ALS culture methods is just the latest in a consistent history of similar failures. Each time the Lyme community concocts some new methodology or clinical association related to Lyme disease reality intrudes in the form of irreproducible results, bad technique, and wishful thinking. And what are the reactions among Lyme activists and their LLMDs to these documented counter-findings? Outrage. Accusations. Conspiracy theories.
ALS/Sapi Culture Methods.
Johnson BJ, Pilgard MA, Russell TM. Assessment of New Culture Method to Detect Borrelia species in Serum of Lyme Disease Patients. J Clin Microbiol. 2013 Aug 14.
Delong’s reinterpretation of the NIH clinical trials.
Klempner MS, et al. Treatment trials for post-lyme disease symptoms revisited. Am J Med. 2013 Aug;126(8):665-9.
Bransfield’s Autism-Lyme Linkage.
1. Burbelo PD, et al. Lack of serum antibodies against Borrelia burgdorferi in children with autism. Clin Vaccine Immunol. 2013 Jul;20(7):1092-3.
2. Ajamian M, Kosofsky BE, Wormser GP, Rajadhyaksha AM, Alaedini A. Serologic markers of Lyme disease in children with autism. JAMA. 2013 May 1;309(17):1771-3.
Stricker’s CD57 Counts.
Marques A, Brown MR, Fleisher TA. Natural killer cell counts are not different between patients with post-Lyme disease syndrome and controls. Clin Vaccine Immunol. 2009 Aug;16(8):1249-50.
Phillips’ “Detroit Water” Cultures.
Marques AR, Stock F, Gill V. Evaluation of a new culture medium for Borrelia burgdorferi. J Clin Microbiol. 2000 Nov;38(11):4239-41.
MacDonald’s Alzheimer Findings.
Marques AR, Weir SC, Fahle GA, Fischer SH. Lack of evidence of Borrelia involvement in Alzheimer's disease. J Infect Dis. 2000 Sep;182(3):1006-7.
Causal relationship between amyotrophic lateral sclerosis (ALS) and Lyme disease.
1. Qureshi, M, Bedlack, RS, and Cudkowicz, ME. Lyme disease serology in amyotrophic lateral sclerosis. Muscle and Nerve 40: 626-628, 2009.
2. The ALSUntangled Group. ALSUntangled update 1: investigating a bug (Lyme Disease) and a drug (Iplex) on behalf of people with ALS. Amyotrophic Lateral Sclerosis 10: 248-250, 2009.
Lyme Urine Assay (LUAT).
Klempner MS, Schmid CH, Hu L et al. Intralaboratory reliability of serologic and urine testing of Lyme disease. Am J Med. 2001;110(3):217-9
Bowen Institute Q-RiBb.
1. Caution regarding testing for Lyme disease. MMWR 2005;54(05):125.
2. Unorthodox and unvalidated laboratory tests in the diagnosis of Lyme borreliosis and in relation to medically unexplained symptoms Prof. Brian I. Duerden, Inspector of Microbiology and Infection Control, Department of Health, U.K. 2010.
Unorthodox applications and interpretations of immunoblots.
1. Halperin JJ, Logigian EL, Finkel MF et al. Practice parameters for the diagnosis of nervous system Lyme borreliosis. Neurology 1996;46(3):619-27
2. V. Seriburi, N. Ndukwe, Z. Chang, M. E. Cox and G. P. Wormser. High frequency of false positive IgM immunoblots for Borrelia burgdorferi in Clinical Practice. Clin Microbiol Infect. 2012 Dec;18(12):1236-40.
3. Notice to Readers: Caution Regarding Testing for Lyme Disease. MMWR. February 11, 2005 / 54(05);125.
4. Johnson, BJ. Laboratory Diagnostic Testing for Borrelia burgdorferi Infection. In Lyme Disease: An Evidence-based Approach, (ed. J.J. Halperin). CAB International 2011.